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Search Results for " lipid metabolism "

39

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4039	BIBB 515	Others	Others
	BIBB 515 是口服具有活力的 2,3-氧化角鲨烯环化酶选择性抑制剂，在大鼠和小鼠中的 ED50值分别为 0.2-0.5 mg/kg 和 0.36-33.3 mg/kg (1-5 小时)。它主要利用抑制低密度脂蛋白的产生，从而发挥降脂作用。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T35343	MTI-31 MTI-31,LXI-15029	mTOR	PI3K/Akt/mTOR signaling
	MTI-31 (LXI-15029) 是口服有效的，高度选择性的mTORC1和mTORC2抑制剂，对 mTOR 的Kd 为 0.20 nM，IC50为 39 nM。MTI-31可用于乳腺癌的研究。
T37958	Acetyl Coenzyme A trisodium Acetyl-CoA trisodium	OXPHOS; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism
	Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) 是糖代谢和脂代谢的重要化合物，参与三羧酸循环。
T22708	Darglitazone CP-86325	PPAR	DNA Damage/DNA Repair; Metabolism
	Darglitazone (CP-86325) 是一种噻唑烷二酮，是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢，在 II 型糖尿病中有研究价值。
T1869	PluriSIn 1 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1	Apoptosis; Dehydrogenase; Stearoyl-CoA Desaturase (SCD)	Apoptosis; Metabolism
	PluriSIn 1 (NSC 14613) 是一种酰基-辅酶 A 去饱和酶抑制剂，是一种多能细胞特异性的抑制剂。
T37735	Stearoyl-L-carnitine chloride C18 Carnitine,Stearoylcarnitine chloride
	Stearoyl-L-carnitine chloride（Acylcarnitine C18:0）是一种存在于小脑中的长链酰基肉碱，抑制 GlyT2 ，是研究脂代谢的重要组成部分。
T67766	HHS-0701	Others	Others
	HHS-0701，一种硫-三唑交换 (SuTEx) 配体，是酪氨酸反应性前列腺素还原酶 2 (PTGR2) 的有效抑制剂。HHS-0701 可以抑制脂质底物 15-Keto-PGE2 的 PTGR2 代谢。
TP2018L	GIP (human) acetate GIP (human) acetate(100040-31-1 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (human) acetate 是葡萄糖依赖性胰岛素分泌的刺激剂和胃酸分泌的弱抑制剂。 GIP (human) acetate 在脂质代谢和肥胖的发展中起着至关重要的作用。
T38715	MSDC-0602K MSDC-0602K,Azemiglitazone potassium	PPAR	DNA Damage/DNA Repair; Metabolism
	MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ...
T10035	10,12-Tricosadiynoic acid TDA,TCDA	Acyltransferase	Metabolism
	10,12-Tricosadiynoic acid 是一种口服有效的酰基辅酶 A 氧化酶-1 (ACOX1) 抑制剂，具有高特异性，选择性，高亲和力的特点。10,12-Tricosadiynoic acid 可改善线粒体脂质和 ROS 代谢，在高脂饮食或肥胖引起的代谢性疾病中有研究的价值。
T62380L	20-HC-Me-Pyrrolidine FA	Others	Others
	20-HC-Me-Pyrrolidine FA 是一种有效的 Aster 蛋白抑制剂，对 Aster-A、Aster-B 和 Aster-C 具有抑制作用，抑制 Aster 蛋白结合和转移胆固醇。20-HC-Me-Pyrrolidine FA 可用于研究脂类代谢。
T3625	Bempedoic acid ETC1002,ESP-55016,ETC 1002,ETC-1002	ATP Citrate Lyase; AMPK	Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling
	Bempedoic acid (ETC1002) 是一种 ATP-柠檬酸裂解酶抑制剂，可激活AMPK。它是脂质和碳水化合物代谢的调节剂。
T8772	Sumaresinolic Acid	Others	Others
	Sumaresinolic Acid 是一种天然木脂素，存在于各种植物中，如亚麻籽、芝麻和麦麸，是植物的次生代谢产物，因其潜在的健康益处而被广泛研究，包括减少炎症、改善脂质代谢和提供抗氧化保护的能力。
T32598	Lauroyl-coenzyme A Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa
	Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport.
T37849	Butafosfan
	Butafosfan is an organic phosphorus supplement that is given, most commonly with cyanocobalamin, to cattle, swine, horses, and poultry for the prevention or treatment of deficiencies. When given with cyanocobalamin, butafosfan alters lipid metabolism, serving to decrease the prevalence of subclinical ketosis.
T37827	CAY10506 CAY10506
	Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 is a hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM.
T13483	RP 54275 2-Octadecyl-1H-indole-5-carboxylic acid	Others	Others
	RP 54275 是一种天然存在的脂肪酸衍生物，一种新的降胆固醇化合物。它可以激活过氧化物酶体增殖物激活受体γ（PPARγ）途径，该途径参与脂质代谢、炎症和细胞分化的调节。
TP2018	GIP, human GIP (human),抑胃肽
	Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and dis
T60629	PF-06649298
	PF-06649298 是一种钠偶联柠檬酸盐转运蛋白抑制剂，可用于调节糖代谢以及脂代谢的研究。PF-06649298 在人类肝细胞中与 NaCT 特异性结合从而抑制柠檬酸盐的转运，IC50值为 16.2 μM。
T38308	Lipoxin B4 methyl ester
	Lipoxin B4 (LXB4) methyl ester is a lipid soluble prodrug form of the transcellular metabolite LXB4 . LXB4 is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15-HpETE by human leukocytes. At a concentration of 100 nM, LXB4 inhibits polymorphonuclear leukocyte (PMN) migration stimulated by leukotriene B4 and inhibits LTB4-induced adhesion of PMNs with an IC50 value of 0.3 nM.
T38389	Prostaglandin D2 Ethanolamide Prostaglandin D2 Ethanolamide
	Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia...
T62576	Darglitazone Sodium
	Darglitazone Sodium 是一种噻唑烷二酮，是一种选择性的、口服具有活力的 PPAR-γ (过氧化物酶体增殖物激活受体)激动剂。Darglitazone Sodium 可以有效控制血糖和脂质代谢，能够用于研究 II 型糖尿病。
T69685	AGPS-IN-2i	MMP	Proteases/Proteasome
	AGPS-IN-2i 是一种高效且具有很高亲和力的烷基甘油磷酸酯合成酶抑制剂的，可控制着细胞中醚脂的利用和代谢，降低了醚类脂质水平和细胞迁移率，促进癌细胞的增殖和运动。AGPS-IN-2i 在 PC-3和 MDA-MB-231癌细胞中测试时通过调节 E-cadherin、Snail 和 MMP2的表达水平，特异性地损害了上皮向间质转化（EMT）。AGPS-IN-2i 对癌细胞增殖具有抑制作用。
T73918	Lauroyl coenzyme A lithium
	Lauroyl coenzyme A lithium salt 是一种辅酶 A。辅酶 A 作为酰基载体，即乙酰辅酶 A。十二烷酰辅酶 A (C12-CoA) 是一种长链 (C-12) 饱和脂肪酰辅酶 A，用作脂质代谢的中间体，参与脂质生物合成和脂肪酸转运。月桂酰辅酶 A 是底物用于 FAM34A 蛋白和萤火虫荧光素酶的产物。
T36052	Lipoxin A4 methyl ester LXA4 methyl ester
	Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM.[2] LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural...
T63220	Bromodomain inhibitor-9
	Bromodomain inhibitor-9 是Bromodomains 抑制剂，可选择性抑制 BRD4-1的活性，其 Kd 值为 12 nM。Bromodomain inhibitor-9 能够用于与全身或脂质代谢、组织炎症、纤维化或慢性自身免疫性疾病相关疾病的研究。
T79783	NSC 48160	Apoptosis	Apoptosis
	NSC 48160对胰腺癌细胞具有抑制作用，IC50分别针对CPFAC-1为84.3μM，对BxPC-3为94.5μM。此外，NSC 48160能够诱导胰腺癌细胞(apoptosis)。该化合物亦能改善代谢综合征症状，包括NASH、肥胖及脂质代谢紊乱。
T36765	Palmitelaidic Acid methyl ester
	Palmitoleic acid is a common constituent of the triglycerides of human adipose tissue. Palmitoleic acid-based diets raise low-density lipoprotein cholesterol and diminish high-density lipoprotein cholesterol, even when dietary intake of cholesterol is maintained at a low level. Palmitelaidic acid is the trans isomer of the 16:1 fatty acid palmitoleic acid. While its effects on cholesterol levels are poorly studied, palmitelaidic acid can have very different effects from those of palmitoleic acid...
T73805	Acetyl coenzyme A
	Acetyl-coenzyme A (Acetyl-CoA) 是一种具有膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A 通过向目标氨基酸残基提供乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A 也是脂质合成的关键前体。
T37620	Leukotriene C4 methyl ester
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all...
T76124	Acyl coenzyme A synthetase
	Acyl coenzyme A synthetase (ACS)，一种生化研究中常用的酶，主要通过两步硫酯化反应激活脂肪酸与辅酶A结合，形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径，以及参与TCA循环中的有氧呼吸提供了关键中间物。
T35547	YW1128
	YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid ac...
T78594	(Z)-KC02
	(Z)-KC02 是一种抑制 ABHD16A 的化合物，后者负责生成溶血-PS。溶血-PS，一种信号脂，参与免疫和神经系统过程，与多种神经系统疾病相关，例如色素性视网膜炎和白内障 (PHARC)。此抑制剂能够降低 PHARC 患者淋巴祖细胞中的 lyso-PS 水平，同时在巨噬细胞中减少 lyso-PS 以及脂多糖诱导的细胞因子产生，进而调控体内 lyso-PS 的代谢。
T37971	12-oxo-13-HOME
	12-oxo-13-HOME is an oxylipin derived from linoleic acid .1It is formedviaa 13-HpODE intermediate that is produced by lipoxygenase-mediated metabolism of linoleic acid.2,3,112-oxo-13-HOME has been found in corn and sunflower seedlings.4 1.Ogorodnikova, A.V., Gorina, S.S., Mukhtarova, L.S., et al.Stereospecific biosynthesis of (9S,13S)-10-oxo-phytoenoic acid in young maize rootsBiochim. Biophys. Acta1851(9)1262-1270(2015) 2.Veldink, G.A., and Vliegenthart, J.F.G.The enzymic conversions of 13-hydr...
T35800	MD001
	MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ.1 It binds to PPARα and PPARγ (Kds = 9.55 and 0.14 μM, respectively) but does not bind to PPARβ/δ at concentrations up to 500 μM. It increases transcriptional activity of PPARα and PPARγ in a cell-based luciferase reporter assay when used at a concentration of 10 μM. MD001 (10 μM) increases expression of PPARα, PPARγ, and retinoid X receptor (RXR), as well as PPARα and PPARγ target genes, in HepG2 cells. It...
T36132	3β-OH-7-Oxocholenic Acid
	3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.2,3 \|1. Norii, T., Yamaga, N., and Yamasaki, K. Metabolism of 7β-hydroxycholesterol-4-14C in rat. Steroids 15(3), 303-326 (1970).\|2. Alvelius, G., Hjalmarson, O., Griffiths, W.J., et al. Identification of unusual 7-oxygenated bile acid sulfates in a patient with Niemann-Pick dise...
T38083	Tunicamycin 17:1 Mixture
	Tunicamycin 17:1 is a mixture of tunicamycin structural isomers that contain a 17-carbon N-acyl chain with variable branching patterns. The N-acyl chain incorporated into tunicamycins, like tunicamycin 17:1, is derived from the same pool of cellular branched-chain fatty acids (BCFAs) inStreptomycesand directly impacts the biological activity of each individual tunicamycin variant.1,2,3Purified tunicamycin 17:1 withisooranteisobranching configurations inhibits bacterial phospho-MurNAc-pentapeptid...
T38082	Tunicamycin 15:1 Mixture
	Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contain a 15-carbon N-acyl chain with variable branching patterns. The N-acyl chain incorporated into tunicamycins, like tunicamycin 15:1, is derived from the same pool of cellular branched-chain fatty acids (BCFAs) inStreptomycesand directly impacts the biological activity of each individual tunicamycin variant.1,2,3Purified tunicamycin 15:1 withiso,anteiso, or a mixture ofisoandanteisobranching configurations inhibit bacteria...

化合物

Cat.No: T4039

Target: Others

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Cat.No: T35343

Synonym: MTI-31,LXI-15029

Target: mTOR

Acetyl Coenzyme A trisodium

Cat.No: T37958

Synonym: Acetyl-CoA trisodium

Target: OXPHOS, Endogenous Metabolite, Autophagy

Cat.No: T22708

Synonym: CP-86325

Target: PPAR

Cat.No: T1869

Synonym: 4-吡啶羧酸 2-苯基酰肼,NSC 14613,PluriSIn #1,PluriSln 1

Target: Apoptosis, Dehydrogenase, Stearoyl-CoA Desaturase (SCD)

Stearoyl-L-carnitine chloride

Cat.No: T37735

Synonym: C18 Carnitine,Stearoylcarnitine chloride

Cat.No: T67766

Target: Others

GIP (human) acetate

Cat.No: TP2018L

Synonym: GIP (human) acetate(100040-31-1 Free base)

Target: IGF-1R

Cat.No: T38715

Synonym: MSDC-0602K,Azemiglitazone potassium

Target: PPAR

10,12-Tricosadiynoic acid

Cat.No: T10035

Synonym: TDA,TCDA

Target: Acyltransferase

20-HC-Me-Pyrrolidine FA

Cat.No: T62380L

Target: Others

Cat.No: T3625

Synonym: ETC1002,ESP-55016,ETC 1002,ETC-1002

Target: ATP Citrate Lyase, AMPK

Sumaresinolic Acid

Cat.No: T8772

Target: Others

Lauroyl-coenzyme A

Cat.No: T32598

Synonym: Dodecanoyl-coa,Coenzyme A, lauroyl-,Lauroyl-coa

Cat.No: T37849

Cat.No: T37827

Synonym: CAY10506

Cat.No: T13483

Synonym: 2-Octadecyl-1H-indole-5-carboxylic acid

Target: Others

Cat.No: TP2018

Synonym: GIP (human),抑胃肽

Cat.No: T60629

Lipoxin B4 methyl ester

Cat.No: T38308

Prostaglandin D2 Ethanolamide

Cat.No: T38389

Synonym: Prostaglandin D2 Ethanolamide

Darglitazone Sodium

Cat.No: T62576

Cat.No: T69685

Target: MMP

Lauroyl coenzyme A lithium

Cat.No: T73918

Lipoxin A4 methyl ester

Cat.No: T36052

Synonym: LXA4 methyl ester

Bromodomain inhibitor-9

Cat.No: T63220

Cat.No: T79783

Target: Apoptosis

Palmitelaidic Acid methyl ester

Cat.No: T36765

Acetyl coenzyme A

Cat.No: T73805

Leukotriene C4 methyl ester

Cat.No: T37620

Acyl coenzyme A synthetase

Cat.No: T76124

Cat.No: T35547

Cat.No: T78594

Cat.No: T37971

Cat.No: T35800

3β-OH-7-Oxocholenic Acid

Cat.No: T36132

Tunicamycin 17:1 Mixture

Cat.No: T38083

Tunicamycin 15:1 Mixture

Cat.No: T38082

Cat. No.	Product Name	Target	Signaling Pathways
TN6772	Malabaricone C	Others	Others
	Malabaricone C 是天然的鞘磷脂合成酶抑制剂，对 SMS 1 和 SMS 2 的IC50分别为 3 和 1.5 μM。
T3804	Neomangiferin Mangiferin 7-glucoside,新芒果苷	Phosphatase	Metabolism
	Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone，分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。
T0700	Ursodeoxycholic acid 熊去氧胆酸,UDCA,Ursodiol	Potassium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	Ursodeoxycholic acid (UDCA)是一种有效的肝脏特异性脂肪酸转运蛋白 5 (FATP5) 抑制剂，通过 FATP5 依赖性方式抑制原代肝细胞摄取长链脂肪酸。Ursodeoxycholic acid 能够抑制胆固醇的吸收，用于溶解胆结石，并具有研究与肥胖相关的脂肪肝疾病的潜力。
T29078	Ursodeoxycholic acid sodium UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium	FXR; Endogenous Metabolite; GPCR19	GPCR/G Protein; Metabolism
	Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸，具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子，通过与胆汁酸激活受体相互作用发挥其作用，包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。
T8714	1-Stearoyl-sn-glycero-3-phosphocholine 1-硬脂酰-SN-甘油-3-磷酰胆碱,1-stearoyl-lysophosphatidylcholine,L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY	Others	Others
	1-Stearoyl-sn-glycero-3-phosphocholine (L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY) 是一种用于脂质代谢研究的化学物质。
T0800	Danthron Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol	Virus Protease; Antibacterial; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Danthron (Antrapurol) 是一种从中药 rhubarb 中提取的天然产物，可通过激活 AMPK 来调节葡萄糖和脂质代谢。
T4461	3,5-Diiodo-L-thyronine 3,5-二碘-L-甲状腺素,Diiodothyronine	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	3,5-Diiodo-L-thyronine (Diiodothyronine) 是内源性代谢产物的一种。
T2867	Diosgenin 山药,Nitogenin	STAT	JAK/STAT signaling; Stem Cells
	Diosgenin (Nitogenin) 是盾叶薯蓣中的一种甾体皂苷，是Pdia3/ERp57的激活剂，能够抑制STAT3信号通路。
T14149	AICAR phosphate AICA Riboside phosphate,Acadesine phosphate	Mitophagy; NOS; YAP; AMPK	Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
	AICAR phosphate (Acadesine phosphate) 是 AMPK 激活剂且是自噬、YAP 和 mitophagy 抑制剂，也是一种腺苷类似物，可调节糖代谢和脂代谢，抑制促炎细胞因子和 iNOS 的产生。
TMA2440	Uridine 5'-monophosphate disodium salt 尿苷-5'-单磷酸二钠盐,Disodium UMP,尿苷酸二钠盐,Disodium uridine-5'-monophosphate,5'-UMP disodium salt,Disodium 5'-Uridylate	Others	Others
	Uridine 5'-monophosphate disodium salt (Disodium UMP) 是合成 RNA 的一种重要成分。
T5249	1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine 1,2-DSPE,1,2-二硬酯酰-SN-甘油-3-磷酰乙醇胺,1,2-Distearoyl-sn-glycero-3-phosphoethan	Others; Endogenous Metabolite	Metabolism; Others
	1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (1,2-DSPE) 是一种磷脂酸乙醇胺 (PE) ，能够用于合成脂质体。
T1039	Choline chloride Biocolina,Biocoline,Hepacholine,氯化胆碱	AChR	Neuroscience
	Choline chloride (Biocoline) 是一种必需营养素，可激活 α7 烟碱受体，具有抗炎、镇痛的活性。对动脉粥样硬化、神经系统疾病和肝脏疾病等具有影响。
T14140	Agaric acid 落叶松蕈酸,Agaricinic Acid	Mitochondrial Metabolism; AChR	Metabolism; Neuroscience
	Agaric acid (Agaricinic Acid) 来一种自真菌部落的Polyporus officinalis 和Polyporus igniarius。它可促进积累的 Ca2+流出，跨膜电位的破坏和线粒体肿胀。它通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。它用于调节脂类代谢。
T3414	Morroniside 莫诺苷,奎宁树	Apoptosis; MMP; Pyroptosis	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用，可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。
T5243	(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate DMPE,1,2-十四酰基磷脂酰乙醇胺,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE	Others; Endogenous Metabolite	Metabolism; Others
	(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) 是内源性代谢产物的一种。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
T34143	Pronuciferine (+)-Pronuciferine
	Pronuciferine ameliorate the glucose and lipid metabolism in insulin-resistant 3T3-L1 adipocytes.
TN3692	Conduritol A	TNF	Apoptosis
	Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting c
T79949	Foenumoside B	PPAR	DNA Damage/DNA Repair; Metabolism
	Foenumoside B为从Lysimachia foenum-graecum中提取的三萜皂苷。该化合物通过激活AMPK信号传导和抑制PPARγ诱导的脂肪生成，调节脂质代谢向脂肪分解方向转变。因其调控作用，Foenumoside B常用于研究肥胖及相关代谢疾病。
T73763	Dihydroxyacetone phosphate hemimagnesium hydrate
	Dihydroxyacetone phosphate 是脂质生物合成和糖酵解中的重要中间产物，参与卡尔文循环和糖酵解等多种代谢途径。此化合物与醛缩酶缺乏症，一种先天性代谢缺陷，相关。
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Cat.No: TN6772

Target: Others

Cat.No: T3804

Synonym: Mangiferin 7-glucoside,新芒果苷

Target: Phosphatase

Ursodeoxycholic acid

Cat.No: T0700

Synonym: 熊去氧胆酸,UDCA,Ursodiol

Target: Potassium Channel, Endogenous Metabolite

Ursodeoxycholic acid sodium

Cat.No: T29078

Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

Target: FXR, Endogenous Metabolite, GPCR19

1-Stearoyl-sn-glycero-3-phosphocholine

Cat.No: T8714

Synonym: 1-硬脂酰-SN-甘油-3-磷酰胆碱,1-stearoyl-lysophosphatidylcholine,L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, STEAROY

Target: Others

Cat.No: T0800

Synonym: Dantron,1,8-Dihydroxyanthraquinone,1,8-二羟基蒽醌,丹蒽醌,Chrysazin,Antrapurol

Target: Virus Protease, Antibacterial, AMPK, Autophagy

3,5-Diiodo-L-thyronine

Cat.No: T4461

Synonym: 3,5-二碘-L-甲状腺素,Diiodothyronine

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T2867

Synonym: 山药,Nitogenin

Target: STAT

AICAR phosphate

Cat.No: T14149

Synonym: AICA Riboside phosphate,Acadesine phosphate

Target: Mitophagy, NOS, YAP, AMPK

Uridine 5'-monophosphate disodium salt

Cat.No: TMA2440

Synonym: 尿苷-5'-单磷酸二钠盐,Disodium UMP,尿苷酸二钠盐,Disodium uridine-5'-monophosphate,5'-UMP disodium salt,Disodium 5'-Uridylate

Target: Others

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine

Cat.No: T5249

Synonym: 1,2-DSPE,1,2-二硬酯酰-SN-甘油-3-磷酰乙醇胺,1,2-Distearoyl-sn-glycero-3-phosphoethan

Target: Others, Endogenous Metabolite

Choline chloride

Cat.No: T1039

Synonym: Biocolina,Biocoline,Hepacholine,氯化胆碱

Target: AChR

Cat.No: T14140

Synonym: 落叶松蕈酸,Agaricinic Acid

Target: Mitochondrial Metabolism, AChR

Cat.No: T3414

Synonym: 莫诺苷,奎宁树

Target: Apoptosis, MMP, Pyroptosis

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate

Cat.No: T5243

Synonym: DMPE,1,2-十四酰基磷脂酰乙醇胺,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE

Target: Others, Endogenous Metabolite

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: T34143

Synonym: (+)-Pronuciferine

Cat.No: TN3692

Target: TNF

Cat.No: T79949

Target: PPAR

Dihydroxyacetone phosphate hemimagnesium hydrate

Cat.No: T73763

(E)-Guggulsterone

Cat.No: T36563

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